Which chemo drugs contain platinum?
Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin, and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or acquired resistance severely limit the clinical application of platinum-based treatment.
What does platinum do in chemotherapy drugs?
Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. They are coordination complexes of platinum. These drugs are used to treat almost half of people receiving chemotherapy for cancer.
Why is platinum used in anti cancer drugs?
Platinum-based drugs are effective against cancer because at their centre is a platinum atom joined to two ammonion molecules and two chloride ions. The compound is negatively charged, but when it enters the cancer cell it becomes positively charged because the chloride ions are replaced by water molecules.
Is all chemotherapy platinum-based?
Platinum-based agents are important drugs or drug candidates for cancer chemotherapy. Traditional platinum drugs including the globally approved cisplatin, carboplatin and oxaliplatin are neutral platinum (II) complexes with two amine ligands and two additional ligands that can be aquated for further binding with DNA.
Is carboplatin platinum-based chemotherapy?
The platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse effects/events).
Does cisplatin contain platinum?
Cisplatin, a platinum-based drug, is used in combination chemotherapy for a wide range of solid tumors.
What are the side effects of platinum chemotherapy?
The range of cisplatin-induced neurotoxicity includes peripheral neuropathy, ototoxicity (hearing impairment and tinnitus), vestibulopathy, and encephalopathy; the most common are peripheral neuropathy and ototoxicity.
What does platinum do to the body?
Nothing could be more un-true. Platinum can cause “platinum sensitivity symptoms”. Platinum toxicity has the ability to cause DNA alterations, cause cancer, allergic reactions of the skin and mucous membranes, it can cause damage to organs such as the kidneys and intestines and has been known to damage hearing ability.
Is Taxol a platinum-based chemotherapy?
Usually, the combination includes a type of chemo drug called a platinum compound (usually cisplatin or carboplatin), and another type of chemo drug called a taxane, such as paclitaxel (Taxol®) or docetaxel (Taxotere®). These drugs are usually given as an IV (put into a vein) every 3 to 4 weeks.
Is carboplatin a platinum-based chemo?
Does platinum chemo cause hair loss?
Taste changes, metallic taste. Increases in blood tests measuring liver function. These return to normal once treatment is discontinued (see liver problems). Hair loss may cause hair loss; however, this side effect is uncommon.
Why is platinum toxic?
The health effects of platinum are strongly dependent upon the kind of bonds that are shaped and the exposure level and immunity of the person that is exposed. Finally, a danger of platinum is that it can cause potentiation of the toxicity of other dangerous chemicals in the human body, such as selenium.
What is platinum based chemotherapy?
Platinum-based chemotherapy consisting of either cisplatin or carboplatin is the usual first-line treatment for inoperable recurrent or metastatic squamous-cell carcinoma of the head and neck. Cisplatin is often combined with fluorouracil, but the results of this treatment are far from satisfactory. 1
What are the names of chemotherapy drugs?
Capecitabine (brand name Xeloda) Capecitabine is used to treat breast cancer and colon and colorectal cancers.
Is platinum a drug?
Doctors use platinum drugs to treat many kinds of cancer, both alone and in combination with other drugs. Cisplatin, the oldest, has been approved as a cancer treatment since 1978. In the U.S., two other platinum-containing molecules are also approved cancer drugs: carboplatin and oxaliplatin.