How does the immune system fight off yellow fever?

Neutralizing antibodies are thought to be the primary correlate of protection against infection with yellow fever virus2,3,11, and immunization is known to protect against infection in more than 90% of vaccinees2,3.

How do you become immune to yellow fever?

Yellow fever is prevented by an extremely effective vaccine, which is safe and affordable. A single dose of yellow fever vaccine is sufficient to grant sustained immunity and life-long protection against yellow fever disease. A booster dose of the vaccine is not needed.

What cells does the yellow fever virus infect?

Yellow fever is characterized by hepatic dysfunction, renal failure, coagulopathy, and shock [5-8]. The midzone of the liver lobule is principally affected, with sparing of cells bordering the central vein and portal tracts [9].

Do dendritic cells fight viruses?

Dendritic cells (DC) are potent antigen-presenting cells that are critical in the initiation of immune responses to control and/or eliminate viral infections.

How does yellow fever affect cells?

What’s to know about yellow fever? Yellow fever is a hemorrhagic condition that can lead to a high fever, bleeding into the skin, and cell death in the liver and kidneys. If enough liver cells die, liver damage occurs, leading to jaundice, a condition in which the skin takes on a yellowish color.

Is yellow fever an RNA virus?

Yellow fever virus is an RNA virus that belongs to the genus Flavivirus. It is related to West Nile, St. Louis encephalitis, and Japanese encephalitis viruses. Yellow fever virus is transmitted to people primarily through the bite of infected Aedes or Haemagogus species mosquitoes.

How do dendritic cells capture viruses?

Dendritic cells (DCs) are among the first cells that recognize incoming viruses at the mucosal portals of entry. Initial interaction between DCs and viruses facilitates cell activation and migration to secondary lymphoid tissues, where these antigen presenting cells (APCs) prime specific adaptive immune responses.

What viruses infect dendritic cells?

Dendritic cells (DCs) act as a portal for virus invasion and as the most potent antigen-presenting cells in antiviral host defense. Human immunodeficiency virus (HIV)-1 has served as the paradigm for virus interaction with DCs.