What are examples of protease inhibitors?

What are examples of protease inhibitors?

Protease inhibitor drugs

  • atazanavir (Reyataz)
  • darunavir (Prezista)
  • fosamprenavir (Lexiva)
  • indinavir (Crixivan)
  • lopinavir/ritonavir (Kaletra)
  • nelfinavir (Viracept)
  • ritonavir (Norvir)
  • saquinavir (Invirase)

How do protease inhibitors cause diabetes?

HIV protease inhibitors (PIs) acutely and reversibly inhibit the insulin-responsive glucose transporter Glut 4, leading to peripheral insulin resistance and impaired glucose tolerance.

What type of inhibitor is protease inhibitor?

Protease inhibitors are a class of antiretroviral medication that people use alongside other HIV drugs to manage HIV effectively. Protease inhibitors work by stopping the activity of HIV protease enzymes, therefore preventing HIV from multiplying.

Is Dolutegravir a protease inhibitor?

Official Answer. No, Triumeq is not a protease inhibitor. It is a combination integrase inhibitor (dolutegravir) and nucleoside reverse transcriptase inhibitor (abacavir / lamivudine) used in the treatment of people living with HIV.

What is a natural protease inhibitor?

Many researchers have classified these plant protease inhibitors into families such as Bowman-Birk, Kunitz, Potato I, Potato II, Serpine, Cereal, Rapeseed, Mustard, and Squash (Laskowski and Qasim, 2000; De Leo et al., 2002). Naturally occurring PIs are abundant in legume seeds.

Are protease inhibitors safe?

In general, protease inhibitors are safe. Patients with other medical conditions will need to be monitored for potential side effects. Tell your healthcare provider about any medications and supplements you are taking before starting a protease inhibitor.

What effect could protease inhibitors have on cholesterol test?

Protease inhibitor therapy also was associated with increased cholesterol levels, but in contrast to triglyceride levels, the linear trend terms for PIs and combination NRTIs were statistically significant as well.

Does darunavir cause hyperglycemia?

Other possible side effects of darunavir include: Diabetes and high blood sugar (hyperglycemia).

What are natural protease inhibitors?

Are protease inhibitors enzymes?

Protease inhibitors are biological or chemical compounds that function by reversibly or irreversibly binding to the protease. Many naturally occurring protease inhibitors are proteins. These enzymes have the ability to break down connective tissue. …

What class of drug is dolutegravir?

Dolutegravir is in a class of medications called HIV integrase inhibitors. It works by decreasing the amount of HIV in your blood and increasing the number of immune cells that help fight infections in your body.

What is Glu-C protease used for?

Description. Glu-C can be used alone or alongside trypsin or other proteases to produce complementary protein digests for peptide mapping and protein sequencing. Glu-C protease is suitable for either in-solution or in-gel digestion workflows. This Glu-C enzyme is packaged lyophilized (5 x 10 µg).

What is endendoproteinase Gluc?

Endoproteinase GluC is a serine proteinase which preferentially cleaves peptide bonds C-terminal to glutamic acid residues. It also cleaves at aspartic acid residues at a rate 100-300 times slower than at glutamic acid residues. Free of glycerol and detergents which may interfere with Mass Spectrometry or liquid chromatography methods.

What is Glu-C used for?

This Glu-C is a mass spectrometry (MS)-grade serine protease isolated from Staphylococcus aureus. Glu-C can be used alone or alongside trypsin or other proteases to produce complementary protein digests for peptide mapping and protein sequencing.

Are NS3/4A protease inhibitors for hepatitis C drug-resistant mutants?

Several small molecule inhibitors of the hepatitis C virus (HCV) NS3/4A protease have advanced successfully to clinical trials. However, the selection of drug-resistant mutants is a significant issue with protease inhibitors (PIs).