What is myeloablative regimen?
Myeloablative treatment plan Myeloablative (high-intensity) stem cell transplant uses high doses of chemotherapy and may use radiation therapy to destroy cancer cells. In this process, bone marrow/stem cells are also destroyed. Patients receive an infusion of new stem cells to rebuild blood and the immune system.
What is a conditioning regimen?
(kun-DIH-shuh-ning REH-jih-men) The treatments used to prepare a patient for stem cell transplantation (a procedure in which a person receives blood stem cells, which make any type of blood cell). A conditioning regimen may include chemotherapy, monoclonal antibody therapy, and radiation to the entire body.
What does engraftment mean?
Engraftment is when the blood-forming cells you received on transplant day start to grow and make healthy blood cells. It’s an important milestone in your transplant recovery.
What is Haploidentical?
A haploidentical transplant is a type of allogeneic transplant. It uses healthy, blood-forming cells from a half- matched donor to replace the unhealthy ones. The donor is typically a family member. For allogeneic transplants, your doctor tests your blood to find out your human leukocyte antigen (HLA) type.
What is myeloablative HSCT?
Myeloablative HSCT is the more stringent type of treatment. This type of HSCT destroys the body’s (autoreactive) lymphocytes as well as the bone marrow. Myeloablative HSCT most commonly incorporates a BEAM (Carmustine, Cytarabine, Etoposide, Melphalan) chemotherapy protocol. The chemotherapy takes place over six days.
What is BMT in chemotherapy?
A procedure in which a patient receives healthy stem cells (blood-forming cells) to replace their own stem cells that have been destroyed by treatment with radiation or high doses of chemotherapy.
What does GVHD stand for?
Graft-versus-host disease (GVHD) is a life-threatening complication that can occur after certain stem cell or bone marrow transplants.
What is Halo transplant?
What is mud transplant?
If you don’t have a good match in your family, a donor might be found in the general public through a national registry. This is sometimes called a MUD (matched unrelated donor) transplant. Transplants with a MUD are usually riskier than those with a relative who is a good match.
What is non myeloablative conditioning regimen?
A non myeloablative conditioning regimen (NMA)is a regimen which will produce minimal cytopenia, and there is no need for stem cell support. A conditioning regimen which does not fulfill MA or NMA is defined as reduced intensity conditioning regim(RIC)
What is myeloablative chemotherapy?
Definition of myeloablative chemotherapy – NCI Dictionary of Cancer Terms – National Cancer Institute High-dose chemotherapy that kills cells in the bone marrow, including cancer cells. It lowers the number of normal blood-forming cells in the bone marrow, and can cause severe side effects.
What is myeloablative conditioning (Mac)?
Myeloablative conditioning (MAC) regimens are those in which TBI and/or chemotherapeutic drugs (usually alkylating agents) are given at doses that do not allow autologous reconstitution and therefore can be fatal to patients without the administration of hematopoietic cells. This approach is often used as conditioning before allogeneic HSCT.
What are the myeloablative conditioning regimens for HSCT?
Myeloablative Conditioning 1 Management of the older patient. Standard myeloablative conditioning regimens for HSCT result in serious extramedullary toxicities to liver, intestine, and lung, and thus the procedure was initially restricted to fit 2 Primary immunodeficiency diseases. 3 Graft failure. 4 TRANSFUSION MEDICINE
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