What is the mechanism of action of voglibose?

What is the mechanism of action of voglibose?

Mechanism of Action The anti-hypoglycaemic action of voglibose results from a reversible inhibition of membrane bound intestines α glycosidase hydrolize enzymes which hydrolize oligosaccharides and disaccharides to glucose and other monosaccharides in the brush border of the small intestine.

How does voglibose work in diabetes?

Voglibose is an alpha-glucosidase inhibitor that is used to treat diabetes mellitus by lowering post-prandial blood glucose levels. It helps to delay the absorption of sugar in the body and thereby it reduces the macrovascular complication risks.

Why is voglibose used?

VOGLIBOSE is used to treat type-2 diabetes mellitus. VOGLIBOSE is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control their blood sugar levels. VOGLIBOSE works inhibiting the intestinal enzymes responsible for breaking complex sugars into simple sugars like glucose.

Is acarbose and voglibose same?

The mean change in SMBG levels 1 hr after dinner in acarbose group was larger than in voglibose group. Based on these results, both drugs were regarded to have similar effects on glycemic control. However, the effects of acarbose on postprandial glucose were slightly superior to those of voglibose.

Which is better voglibose or Teneligliptin?

The study concluded that in diabetic patients with ESRD, teneligliptin significantly improved glycemic control and was well tolerated. Teneligliptin appeared to be more potent than voglibose or vildagliptin based on its glucose-lowering effects.

What is the difference between voglibose and glimepiride?

Fasting blood glucose levels tended to be reduced to a greater extent in the glimepiride group than in the mitiglinide/voglibose group (-13.9% vs. -8.4%, p=0.08), while the rate of reduction of HbA1c levels tended to be higher in the mitiglinide/voglibose group than in the glimepiride group (-6.9% vs.

Which is better voglibose or metformin?

Metformin lowers the production and absorption of sugar in your body and allows better use of existing insulin. Voglibose inhibits the intestinal enzymes that cause breakdown of complex sugars into simple sugars such as glucose. This prevents blood glucose from rising very high after meals.

What is the composition of voglibose?

Volibo M 0.3mg Tablet 10’s is composed of two medicines, namely voglibose and metformin. Voglibose belongs to the class of alpha-glucosidase inhibitors. It is used in the treatment of diabetes mellitus and acts by delaying glucose absorption.

Which is better pioglitazone or voglibose?

Conclusions: Though pioglitazone and voglibose were equally effective in lowering Blood glucose levels yet pioglitazone showed better results in improving FBG, as compared to voglibose. Furthermore, voglibose presented better results in controlling PPBG, as compared to Pioglitazone.

Is voglibose better than acarbose?

We conclude that both voglibose (0.2 mg) and acarbose (100 mg) thrice daily significantly decreased HbA(1c), PPBG and postprandial insulin levels. At these dose levels, voglibose was associated with less gastrointestinal side effects and slightly less efficacy for postprandial glucose reduction.

Which is better Voglibose or vildagliptin?

Gastrointestinal AEs were significantly lower with vildagliptin compared with that of the voglibose (18.6 vs. 32.8%; p = 0.002). Conclusions: Vildagliptin (50 mg bid) showed superior efficacy and better tolerability compared with voglibose in Japanese patients with T2D.

Is vildagliptin and Voglibose same?

The between-treatment difference (vildagliptin–voglibose) in adjusted mean change in HbA1c reduction was significant [0.57 ± 0.06%, 95% CI (−0.68 to −0.46%), p < 0.001], demonstrating that vildagliptin 50 mg bid was superior to voglibose 0.2 mg tid (Figure 2B).

What is the mechanism of action of variablevoglibose?

Voglibose is an alpha-glycosidase inhibitor. Alpha glucosidase inhibitor delays the glucose absorption at the intestine level and prevents sudden increase of glucose after meal.

What is the use of Voglibose?

Voglibose is an alpha-glucosidase inhibitor indicated in the management of postprandial blood glucose in patients with type II diabetes. Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. It is made in India by Ranbaxy Labs and sold under the trade name Volix.

Does Voglibose interact with other medications or foods?

Voglibose can trigger adverse reactions in the presence of medical conditions/diseases. It can also interact with other medicines, vitamins and supplements, therefore it is imperative to disclose your complete medical history, drugs you take or are allergic with your medical specialist.

What are the pharmacokinetic parameters of Voglibose with metformin?

The reported pharmacokinetic parameters of voglibose with metformin are Cmax corresponds to 1.38 mcg/ml while AUC is 8.17 mcg.h/ml and tmax is of 2.5 hours. 4 Little metabolism occurs and no metabolites have as yet been identified.