What is the mechanism of action of clarithromycin?
Clarithromycin prevents bacteria from multiplying by acting as a protein synthesis inhibitor. It binds to 23S rRNA, a component of the 50S subunit of the bacterial ribosome, thus inhibiting the translation of peptides.
What is the mechanism of action of clindamycin?
Clindamycin works primarily by binding to the 50s ribosomal subunit of bacteria. This agent disrupts protein synthesis by interfering with the transpeptidation reaction, which thereby inhibits early chain elongation.
What is the function of clarithromycin?
About clarithromycin Clarithromycin is an antibiotic. It’s used to treat chest infections, such as pneumonia, skin problems such as cellulitis, and ear infections. It’s also used to get rid of Helicobacter pylori, a bacteria that can cause stomach ulcers.
Is Biaxin a cephalosporin?
Biaxin (clarithromycin) is a macrolide antibiotic prescribed for certain bacterial infections including skin and middle ear infections, tonsillitis, throat infections, laryngitis, pneumonia, and tuberculosis. Biaxin is available in generic form.
Is clarithromycin an enzyme inducer?
Clarithromycin is an inhibitor of the P-450 enzyme system, and its use results in increased serum levels and potential increased toxicities of multiple drugs metabolized by these enzymes, including rifabutin,86,87 carbamazepine, cisapride, astemizole, terfenadine, and theophylline.
How is clindamycin made?
Clindamycin is a semisynthetic derivative of lincomycin, a natural antibiotic produced by the actinobacterium Streptomyces lincolnensis. It is obtained by 7(S)-chloro-substitution of the 7(R)-hydroxyl group of lincomycin.
What is the difference between clindamycin and clarithromycin?
Human-like kinetics of the two antibiotics prevented endocarditis in animals challenged with both small and large amounts of bacterial inocula. Clarithromycin was marginally superior to clindamycin against small amounts of inocula. Clarithromycin may be considered for endocarditis chemoprophylaxis in human.
Is clarithromycin a sulfa drug?
Biaxin (clarithromycin) is not a sulfa-based drug, and those with a known allergy to medicines that contain sulfa are not at risk of having an allergic reaction to clarithromycin.
Which is better clarithromycin or Augmentin?
Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections. Treats bacterial infections. Biaxin (clarithromycin) is a good first-choice medicine to treat most common respiratory infections.
Is Biaxin sulfa based?
Official Answer. Biaxin (clarithromycin) is not a sulfa-based drug, and those with a known allergy to medicines that contain sulfa are not at risk of having an allergic reaction to clarithromycin.
How does protein affect serotonin and catecholamine synthesis?
Meal ingestion, amino acids and brain neurotransmitters: effects of dietary protein source on serotonin and catecholamine synthesis rates Carbohydrate ingestion raises tryptophan uptake and serotonin synthesis in rat brain. The addition of protein is generally believed only to block such increases.
Does dietary protein intake affect serotonin synthesis in rat brain?
Meal ingestion, amino acids and brain neurotransmitters: effects of dietary protein source on serotonin and catecholamine synthesis rates Carbohydrate ingestion raises tryptophan uptake and serotonin synthesis in rat brain.
What is the biochemical pathway for serotonin synthesis?
The biochemical pathway for serotonin synthesis initially involves the conversion of L-tryptophan to 5-hydroxytryptophan by the enzyme L-tryptophan hydroxylase (TPH), which has been found both in cytosolic and particulate brain cell fractions.
How is serotonin synthesized from L-DOPA?
The subsequent metabolic step in the synthesis of serotonin (and also norepinephrine or dopamine) involves the decarboxylation of 5-hydroxytryptophan (and L-DOPA) by the action of the cytosolic enzyme L-aromatic amino acid decarboxylase.